Unraveling the Biological and Environmental Triggers of Knee Osteoarthritis

Knee osteoarthritis is a prevalent condition marked by cartilage breakdown, pain, and decreased mobility. This article examines the biological and lifestyle factors behind its development, including genetics, aging, chronic inflammation, excess body weight, and repetitive strain from daily activities. It highlights how environmental triggers combine with internal processes to accelerate joint damage and inflammation, ultimately impacting quality of life. Prevention and treatment strategies focus on maintaining a healthy weight, staying active, and individualized therapy based on one’s risk profile. Understanding these mechanisms is essential for effective management and offers hope for more targeted, personalized interventions in the future.