Decoding Diagnostic Clues: The Role of Synovial Fluid Analysis in Personalized Management of Knee Osteoarthritis

Knee osteoarthritis, marked by cartilage deterioration and joint pain, is closely linked to changes in synovial fluid—the joint’s natural lubricant and shock absorber. Synovial fluid, rich in hyaluronan and lubricin, is key to smooth joint movement. In osteoarthritis, alterations in this fluid, including increased inflammatory markers, contribute to pain and stiffness. Analyzing synovial fluid helps in early detection, diagnosis, and prognosis of the disease, enabling personalized treatment strategies that may slow progression and improve mobility. This approach holds promise for tailored therapies enhancing patient outcomes and quality of life.