Introduction
Knee osteoarthritis is a common condition that can significantly restrict movement and impact everyday life. As joint cartilage wears down over time, many people search for treatments to ease chronic pain and keep active. One emerging therapy gaining attention is Arthrosamid, a novel injection offering the promise of longer-lasting relief. This article explains how long Arthrosamid injections usually last, who might benefit most, and what factors can influence the results. The information is backed by current medical studies and aims to help you have informed conversations with your healthcare provider.
What Is Arthrosamid and How Does It Work?
Arthrosamid is an injection made from a special gel called polyacrylamide hydrogel. Unlike some treatments that the body quickly absorbs, this gel stays inside the knee joint, acting as a cushioning buffer. This helps reduce friction and soothe pain caused by osteoarthritis wear and tear.
Experts say Arthrosamid “fulfils an unmet clinical need for an effective, long-acting and safe non-surgical treatment that may postpone knee surgery for those with OA” (Bliddal et al., 2023). Compared to other common injections, such as corticosteroids that ease inflammation or hyaluronic acid which lubricates the joint temporarily, Arthrosamid’s unique gel structure aims to provide longer-lasting support.
Typically, it's recommended for patients with moderate to severe knee osteoarthritis who have not found enough relief from other injections or who prefer to delay surgery.
How Long Does Arthrosamid Relief Last?
Studies suggest that Arthrosamid can provide pain relief lasting from one up to three years. Its stable gel composition means it remains in the joint longer than many other treatments.
In fact, a clinical trial found that “single injections ... continue to provide clinically relevant and statistically significant effectiveness at 3 years after treatment” (Bliddal et al., 2023). Patients saw meaningful improvements in pain, stiffness and ability to function during this period.
Another recent study compared Arthrosamid with hyaluronic acid and corticosteroids, finding that while “long-term superiority is limited,” patients treated with Arthrosamid “at 12 months … remained slightly improved” compared to others (Aykaç et al., 2025). This means Arthrosamid may keep pain at bay longer than some alternatives, though results can vary.
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What Influences How Long Arthrosamid Injections Last?
The length of relief can differ from person to person. Factors that play a role include how severe the osteoarthritis is, your body weight (which affects knee pressure), and your activity levels. People with less damage to their joints and a healthy lifestyle might enjoy longer-lasting benefits.
Safety is also reassuring. The three-year study reported no serious treatment-related side effects despite some adverse events during the study period: “none of the new events were assessed as related to treatment” (Bliddal et al., 2023).
Other treatments such as physiotherapy and exercises, plus taking care of overall knee health, can help maximise and prolong the advantages of the injection. Repeat injections are possible if pain returns, with timing guided by your doctor.
How Does Arthrosamid Compare to Other Knee Injections?
When compared directly, Arthrosamid stands out for its longer-lasting effects than corticosteroids and hyaluronic acid. Corticosteroids usually give quick but short relief, and repeated use is limited due to side effects. Hyaluronic acid injections require multiple doses per year and may not last beyond 6 to 12 months.
One study reported that “iPAAG outperformed Steroid at 6 months... but not HA” and that “iPAAG showed the highest patient acceptable symptom state rates (72%, 54%, and 42% at 3, 6, and 12 months)” (Aykaç et al., 2025). Another noted that Arthrosamid “fulfils an unmet clinical need for an effective, long-acting and safe non-surgical treatment” (Bliddal et al., 2023).
Of course, availability, cost, and NHS funding may vary, making it important to discuss the best option with your healthcare provider.
Frequently Asked Questions
Can you have Arthrosamid injections more than once?
Yes. Repeat injections are generally safe and can be effective when spaced appropriately under medical guidance.
Will I get relief for the same length of time as others?
Not exactly. Duration depends on factors like how advanced your arthritis is, your weight, activity level, and following therapy advice.
Are there reasons why the injection might not last long?
Severe joint damage or high mechanical stress on the knee may shorten how long the relief lasts.
What should I ask my doctor before deciding?
Talk about your medical history, previous treatments, lifestyle, and goals to see if Arthrosamid is the right fit for you.
Conclusion
In summary, Arthrosamid injections can provide meaningful knee pain relief lasting a year or more, with strong evidence supporting benefits for up to three years in many cases. While the length of relief varies by individual, Arthrosamid often lasts longer than many other commonly used injections. As with any treatment, it is vital to consult your healthcare professional to get personalised advice and determine the best schedule for injections. Keeping track of your symptoms and discussing them during appointments will help get the most from your care. Staying informed about new advances empowers you to make the best choices for your knee health and quality of life.
References
- Cole, A., Maulana, R. K., Whitehead, J. P., & Lee, P. Y. F. (2022). A systematic review of the novel compound Arthrosamid Polyacrylamide (PAAG) hydrogel for treatment of knee osteoarthritis. Medical Research Archives, 10(8). https://doi.org/10.18103/mra.v10i8.2950
- Bliddal, H., Beier, J., Hartkopp, A., Conaghan, P. G., & Henriksen, M. (2023). Polyacrylamide hydrogel for the treatment of knee osteoarthritis: 3 year follow up results of a prospective clinical study. Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2023-eular.6038
- Aykaç, B., Dinç, M., Nar, Ö. O., Karasu, R., & Bayrak, H. Ç. (2025). Comparative efficacy of polyacrylamide hydrogel versus hyaluronic acid and corticosteroids in knee osteoarthritis: A retrospective cohort study. Medicine, 104(38), e44655. https://doi.org/10.1097/md.0000000000044655
Frequently Asked Questions
- Arthrosamid® injections at AMSK Clinic use a unique polyacrylamide hydrogel that remains longer in the knee joint. This longer-lasting cushioning can provide durable pain relief, setting AMSK Clinic apart with advanced, non-surgical therapy for knee osteoarthritis sufferers.
- Patients with moderate to severe knee osteoarthritis, especially those not finding enough relief from traditional injections or preferring to delay surgery, are likely to benefit most from Arthrosamid® treatment at AMSK Clinic’s experienced team.
- Most patients treated at AMSK Clinic report relief lasting from one up to three years, supported by recent clinical evidence. The exact duration varies depending on individual factors, but AMSK Clinic’s approach helps maximise the effectiveness of each injection.
- Yes, repeat Arthrosamid® injections are generally safe under medical supervision. AMSK Clinic’s clinicians carefully guide timing and assess individual needs, ensuring ongoing safety and the best possible results for persistent knee osteoarthritis pain.
- AMSK Clinic offers extensive experience, advanced facilities, and personalised care, ensuring optimal results with Arthrosamid® injections. Their comprehensive approach supports patients throughout the entire process, from consultation to aftercare, maximising treatment benefits and knee health outcomes.
Legal & Medical Disclaimer
This article is written by an independent contributor and reflects their own views and experience, not necessarily those of AMSK. It is provided for general information and education only and does not constitute medical advice, diagnosis, or treatment.
Always seek personalised advice from a qualified healthcare professional before making decisions about your health. AMSK accepts no responsibility for errors, omissions, third-party content, or any loss, damage, or injury arising from reliance on this material.
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