Introduction

Knee osteoarthritis is a common and often painful condition where the protective cartilage in the knee gradually wears away, causing discomfort and difficulty moving. Managing this ongoing pain can be a tough challenge for many people. Arthrosamid is a relatively new injectable treatment designed to provide longer-lasting relief from the symptoms of knee osteoarthritis. In this article, we’ll delve into how long Arthrosamid injections typically last, bringing together evidence from clinical studies and patient reports. It’s aimed at those considering Arthrosamid, helping you set realistic expectations around how long the effects last and whether repeat injections might be needed. We’ll also compare Arthrosamid to other commonly used treatments, helping you understand where it fits within knee osteoarthritis management.

Typical Duration of Arthrosamid’s Effect

Research and patient feedback suggest that the benefits of Arthrosamid usually last between 12 and 24 months, with some people experiencing relief for as long as 3 to 5 years. To clarify, when we talk about “duration of effect,” we mean how long patients enjoy meaningful reductions in pain and improved knee function after the injection. One comprehensive review of available studies found clear evidence of Arthrosamid’s effectiveness lasting “at both 52 weeks and 13 months,” with further data showing benefits maintained for up to two years (Cole et al., 2022). This highlights that Arthrosamid is not only effective but also safe, offering hope for sustained symptom control well beyond the short-term.

The Arthrosamid Outcomes Timeline: Onset, Peak, and Sustainability

Once the Arthrosamid injection is administered, patients usually begin to notice pain relief within a few weeks. The full effect typically peaks between three to six months, when symptom improvement is at its greatest. After this, many patients continue to benefit from substantial pain relief, which gradually tapers off over time. Interestingly, a recent clinical study showed that Arthrosamid was particularly effective in certain groups—those under 70 years old, individuals with a normal body mass index (BMI), and patients with moderate osteoarthritis (Bliddal et al., 2023). These findings suggest some people may experience especially strong and lasting benefits. However, everyone's experience differs, often depending on the severity of their arthritis and overall health.

Factors Influencing How Long Arthrosamid Lasts

Several factors determine how long the effects of Arthrosamid last for each individual. A more active lifestyle or severe arthritis can shorten the duration of pain relief, while those with milder symptoms or better general health often enjoy longer-lasting benefits. The trial mentioned earlier underlined that Arthrosamid “represents a useful alternative to hyaluronic acid for knee osteoarthritis treatment,” especially in younger patients or those with moderate joint damage (Bliddal et al., 2023). This variability in outcomes emphasises the importance of personalising treatment plans in discussion with healthcare professionals.

Repeat Injections: When and What to Expect

As with many treatments for knee osteoarthritis, the effects of a single Arthrosamid injection may diminish over time. When this happens, repeat injections are often considered to maintain symptom relief. Clinical experience shows that these repeats can generally be given safely and are typically spaced about 1 to 2 years apart, depending on how long the initial relief lasts. Compared with other injection therapies, Arthrosamid usually requires fewer repeat treatments, which can be a significant benefit in the long-term care of knee osteoarthritis. Being aware of the possibility and timing of repeat injections can help patients plan their ongoing management more effectively.

How Arthrosamid Compares to Traditional Knee Osteoarthritis Injections

Arthrosamid stands out by offering longer-lasting relief than many traditional injections, such as hyaluronic acid or corticosteroids. For context, corticosteroids often bring quick but short-lived improvements, usually limited to a few weeks or months, while hyaluronic acid injections typically last between six and twelve months. By comparison, Arthrosamid’s beneficial effects can last a year or more, sometimes even several years.

One study found that at 52 weeks, Arthrosamid was almost superior to hyaluronic acid in reducing pain, with statistically significant advantages in some patient groups, including those with a normal BMI and less severe arthritis (Bliddal et al., 2023). Another retrospective study reported that while pain and function scores from hyaluronic acid and corticosteroid injections returned to baseline at 12 months, Arthrosamid’s benefits remained stable, with a higher percentage of patients reporting acceptable symptom control (Aykaç et al., 2025).

That said, it’s important to remember that no injection cures osteoarthritis permanently. Arthrosamid is best viewed as a valuable tool within a broader, long-term management plan that includes lifestyle modifications and other treatments.

Conclusion: Setting Realistic Expectations for Long-Term Relief

All in all, Arthrosamid typically provides meaningful pain relief for 12 to 24 months, though some patients experience benefits lasting 3 to 5 years. How long it lasts depends on individual factors like activity level, arthritis severity, and overall health. Repeat injections may be necessary but are usually well spaced, making Arthrosamid a convenient option for many. It offers a promising choice for those seeking sustained symptom control and can complement other treatments effectively. If you’re considering Arthrosamid, it’s best to consult your healthcare provider for personalised advice and to keep up to date with emerging research on treatment durability.

References

Cole, A., Maulana, R. K., Whitehead, J. P., & Lee, P. Y. F. (2022). A systematic review of the novel compound Arthrosamid polyacrylamide (PAAG) hydrogel for treatment of knee osteoarthritis. Medical Research Archives, 10(8). https://doi.org/10.18103/mra.v10i8.2950
Bliddal, H., Beier, J., Hartkopp, A., Conaghan, P. G., & Henriksen, M. (2023). Polyacrylamide hydrogel versus hyaluronic acid in knee osteoarthritis: A subgroup analysis of a randomised study. Orthopaedic Proceedings, 105-B(SUPP_13), 81–81. https://doi.org/10.1302/1358-992x.2023.13.081
Aykaç, B., Dinç, M., Nar, Ö. O., Karasu, R., & Bayrak, H. Ç. (2025). Comparative efficacy of polyacrylamide hydrogel versus hyaluronic acid and corticosteroids in knee osteoarthritis: A retrospective cohort study. Medicine, 104(38), e44655. https://doi.org/10.1097/md.0000000000044655