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Arthrosamid®’s story started two decades ago. The brainchild of the team at Contura, the product had been in human use for various indications since 2000, and a favourable safety profile had already been established.

Arthrosamid vs Corticosteroid Injections for Knee Osteoarthritis: Finding Steadier, Longer-Lasting Joint Comfort

Introduction

Imagine waking up each morning to aching knees. Tasks as simple as climbing stairs or taking a short walk become uncomfortable challenges. If you’re living with osteoarthritis —the most common form of joint wear and tear—you likely know this struggle all too well.

When it comes to easing knee pain, two popular injectable treatments are often considered: Arthrosamid and corticosteroid injections . Arthrosamid is a gel-like substance designed to cushion and protect the joint, while corticosteroids are medications that quickly reduce inflammation. But which option provides more reliable, longer-lasting relief?

In this article, we’ll break down how each treatment works, how effective they are, their safety profiles, and who benefits most from each—giving you the insights needed to make informed decisions about managing osteoarthritis pain.

How Arthrosamid and Corticosteroids Ease Pain

Arthrosamid and corticosteroids offer relief in very different ways.

Arthrosamid is a polyacrylamide hydrogel injected directly into the knee. Think of it as adding a soft, supportive cushion inside your joint—replacing some of the natural padding lost through cartilage wear and tear. This added cushioning helps absorb the impact from movement, leading to smoother, less painful mobility.

Corticosteroids, on the other hand, act like powerful fire extinguishers. When injected, they quickly calm inflammation by blocking the chemicals that cause swelling and pain inside the joint. This can bring fast relief during painful flare-ups, but unlike Arthrosamid , corticosteroids don’t add cushioning or repair joint structures.

In short, Arthrosamid cushions and supports your knee over time, while corticosteroids rapidly reduce inflammation for short-term relief. Understanding this core difference is key when considering what kind of comfort you want from your treatment.

How Effective Are They, and How Long Does Relief Last?

Effectiveness and duration of relief are important when choosing between these treatments.

Corticosteroid injections are known for their speed. Most people notice improvement within a week or two, and relief peaks around 4 to 6 weeks. However, the benefits often fade after about three months, and symptoms can return.

Arthrosamid works more gradually but delivers long-lasting results. Improvement may begin within a month, and studies show relief can last a year or even longer. Patients consistently report steadier, more enduring comfort, with many experiencing benefits for up to two years. Clinical research using established pain and function scores confirms that Arthrosamid can deliver meaningful, sustained relief for knee osteoarthritis .

To sum up:

  • Corticosteroids: Quick relief within weeks, but effects often wear off in about three months.
  • Arthrosamid : Gradual improvement, with lasting comfort for 12 months or more.

If you are looking for extended relief and want to avoid repeated injections, Arthrosamid may hold a key advantage.

What About Safety and Side Effects?

Both treatments have established safety profiles but carry different considerations.

Corticosteroid injections can sometimes cause a temporary increase in pain or swelling, known as a post-injection flare. They may also cause a brief rise in blood sugar levels, so people with diabetes should be cautious. With repeated use, corticosteroids can gradually weaken tendons or joint tissues, making them less desirable for long-term, frequent use.

Arthrosamid has a strong track record for safety, backed by over 20 years of worldwide use. The gel stays within the joint and doesn’t affect the rest of the body, limiting the risk of systemic side effects. Most issues are mild, such as temporary discomfort or swelling at the injection site, and serious complications are rare. While occasional minor side effects have been reported, overall, the procedure is considered very safe. As with any medical treatment, it’s important to report persistent redness, swelling, or pain to your healthcare provider.

No matter which option you pursue, following your doctor’s instructions and monitoring for any unusual symptoms is essential to minimize risks.

Which Treatment Is Right for Me?

Deciding on the best treatment is a personal choice and depends on your symptoms, health status, and lifestyle.

Corticosteroid injections are great for those experiencing a sudden, painful flare-up who need quick relief to stay active. Since their benefits tend to fade after a few months and they carry risks with repeated use, they aren’t usually recommended as a long-term solution.

Arthrosamid is better suited for people with moderate to severe, persistent knee osteoarthritis who want steady, longer-lasting relief. Research suggests older adults, those with less severe osteoarthritis , and people without diabetes are most likely to benefit.

Ultimately, the most effective way to choose is by discussing your options in depth with your doctor. Considering your daily activities, other health concerns, and your personal goals will help you and your provider select a treatment plan that fits your life.

Conclusion

Corticosteroid injections provide fast but temporary relief for knee osteoarthritis , while Arthrosamid offers a gentler, longer-lasting solution by cushioning the joint. Both have an important role, depending on your individual needs and goals.

If knee pain is holding you back, talk to your healthcare provider about these treatment options. With ongoing advances in osteoarthritis care, therapies like Arthrosamid are opening new doors to lasting comfort and a better quality of life.

Understanding what each treatment provides can help you make confident decisions in your journey toward better movement and greater joint comfort.

If you’d like help exploring treatment options or have questions about osteoarthritis management , consult your healthcare professional for personalized advice.

References:

  1. Gao, H. C. K., Akhtar, M., Creedon, C., Nar, Ö. O., Verma, T., & Lee, P. Y. F. (2025). Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24 month cohort study. Journal of Clinical Orthopaedics and Trauma. https://doi.org/10.1016/j.jcot.2025.103136
  2. Örücü Atar, M., Yaşar, E., Tezen, Ö., Bilgin, E., Yurtoğulları, Ş., Köroğlu, Ö., & Gürçay, E. (2022). Ultrasound-guided hydrodissection with corticosteroid injection for carpal tunnel syndrome. Fiziksel Tıp Ve Rehabilitasyon Bilimleri Dergisi, 25(3), 299-306. https://doi.org/10.31609/jpmrs.2022-88198
  3. Arthrosamid patient guides and trial results
  4. Safety data and long-term outcomes for Arthrosamid injections

Frequently Asked Questions

Arthrosamid® is a gel that cushions and supports the knee joint, whereas corticosteroid injections focus on reducing inflammation quickly. AMSK Clinic recommends Arthrosamid® for those seeking steady, long-lasting pain relief rather than just immediate, short-term comfort.

Corticosteroids typically provide relief lasting up to three months, while Arthrosamid® often results in gradual and longer-lasting comfort. Many AMSK Clinic patients report benefits from Arthrosamid® lasting a year or longer, making it preferable for sustained management.

Both injections are considered safe at AMSK Clinic, but each has unique considerations. Corticosteroids can cause brief flares or raise blood sugar temporarily. Arthrosamid® rarely causes anything more than mild discomfort or swelling, with serious complications being extremely uncommon.

At AMSK Clinic, Arthrosamid® is ideal for those with moderate to severe, ongoing osteoarthritis seeking extended relief. Corticosteroids suit people needing rapid relief from sudden flare-ups but aren’t usually advised for frequent, long-term use due to tissue risks.

AMSK Clinic offers advanced expertise, a dedicated team, and leading treatments like Arthrosamid®. Their patient-centred care ensures you receive tailored options, supporting your journey to greater comfort, movement and a better quality of life with innovative, evidence-based therapies.

Deciding if Arthrosamid Injection Is Right for You: Patient Profiles, Key Criteria, and a Step-by-Step Candidacy Guide

Arthrosamid is an innovative injection treatment for adults with mild to moderate knee osteoarthritis who have not found sufficient relief from traditional therapies like painkillers, physiotherapy, or steroid/hyaluronic acid injections. It works by cushioning and supporting the joint with a durable gel, potentially providing longer-lasting pain relief and improved mobility for up to a year or more. Ideal candidates are typically older adults around 70, those with symptoms in both knees, and individuals without infections, recent surgery, or allergies to the gel’s components. Clinical studies show Arthrosamid is safe and effective even for up to three years. Before considering this option, patients should consult healthcare providers for a thorough assessment and shared decision-making to ensure the treatment fits their medical profile and personal needs.

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Arthrosamid vs Corticosteroid Injections for Knee Osteoarthritis: Finding Steadier, Longer-Lasting Joint Comfort

Arthrosamid and corticosteroid injections are common treatments for knee osteoarthritis pain. Arthrosamid, a polyacrylamide hydrogel, cushions and supports the knee, providing gradual but long-lasting relief lasting up to two years. Corticosteroids reduce inflammation quickly, offering fast relief that typically lasts about three months. Both treatments are safe with distinct side effects, making patient-specific factors crucial in choosing the right option. Arthrosamid suits those seeking extended comfort, while corticosteroids are ideal for sudden flare-ups. Consulting a healthcare provider helps tailor the best approach for managing osteoarthritis pain effectively.

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