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Arthrosamid®’s story started two decades ago. The brainchild of the team at Contura, the product had been in human use for various indications since 2000, and a favourable safety profile had already been established.

Evaluating Functional Gains in Knee Osteoarthritis: Comparing the Oxford Knee Score and Lysholm Scale After PAAG Treatment

Introduction

Knee Osteoarthritis (OA) is a widespread condition where the protective cartilage in the knee joint wears away over time. This leads to pain, stiffness, and reduced mobility, making everyday activities—from climbing stairs and walking on sidewalks to playing sports—much more challenging.

To measure whether treatments are truly helping, healthcare professionals use specific tools that assess knee function from the patient’s perspective. Two of the most trusted are the Oxford Knee Score (OKS) and the Lysholm scale. Recently, a treatment called Polyacrylamide Gel (PAAG) has shown promising results in restoring knee function in OA patients. This article examines how the OKS and Lysholm scale capture improvements after PAAG treatment, highlighting their strengths in assessing both routine daily activities and more demanding movements.

Why Accurate Assessment Matters in Knee Osteoarthritis

Knee OA affects much more than just the joint—it impacts daily life and independence. Reliable assessment tools are crucial for tracking progress, evaluating treatment effectiveness, and creating personalised rehabilitation plans.

The Oxford Knee Score was initially created to measure recovery after knee replacement surgery , but its straightforward questionnaire makes it useful for tracking a wide range of knee issues. The OKS assesses how pain and physical limitations interfere with simple tasks like walking or using stairs.

The Lysholm scale, on the other hand, started as a tool for evaluating knee ligament injuries, but it has proven valuable for OA patients—especially those aiming to return to sports or higher-level activities. It measures symptoms like swelling, locking, and limping, which are particularly relevant for active individuals.

Since PAAG is an innovative treatment for Knee OA, using both OKS and Lysholm offers a more complete understanding of recovery, from basic walking to vigorous activity.

Understanding the Oxford Knee Score and Lysholm Scale

The Oxford Knee Score (OKS)

The OKS is a simple 12-question survey that asks patients about pain and function in daily life. Each item is scored from 0 to 4, with higher totals reflecting better knee health. The OKS is especially practical for monitoring improvements after treatment, as it’s sensitive enough to pick up even small positive changes. This makes it a great tool for gauging the impact of treatments like PAAG over time.

The Lysholm Scale

The Lysholm scale measures eight symptoms, including limp, locking, swelling, instability, and the ability to climb stairs and squat. Scores range from 0 to 100, where higher scores indicate better knee function. The Lysholm scale is particularly valued for its focus on knee stability and athletic movements, making it especially useful for patients wishing to return to sports or other physically demanding activities.

How These Tools Compare

While the OKS and Lysholm scale both evaluate knee function, they emphasise different aspects of recovery. The OKS is ideal for tracking improvements in day-to-day tasks, making it especially relevant for regaining mobility in daily life.

The Lysholm scale pays closer attention to knee stability and symptoms that matter for athletes or those with more physically demanding lifestyles. It’s more sensitive to issues like swelling or giving way, providing insight into readiness for higher-impact activities.

For patients treated with PAAG, using both tools together paints the most complete picture. The OKS highlights progress in reducing pain and restoring routine function, while the Lysholm scale tracks gains in stability and advanced movement. This dual approach allows doctors to personalise rehabilitation, focusing on each patient’s unique goals—whether that’s walking comfortably on a sidewalk or getting back to the pitch.

What This Means for Treatment and Future Research

Combining the Oxford Knee Score and Lysholm scale in clinical practice offers valuable, nuanced feedback on a patient’s progress after PAAG treatment. For example, a patient may report less pain and better everyday function (a higher OKS), but could still need targeted physiotherapy to regain strength and stability for sports (as shown by the Lysholm scale).

Looking to the future, research can leverage these measurement tools to test how PAAG works alongside other therapies, refine patient selection, and evaluate long-term results. Regular, evidence-based assessment enables healthcare providers to adapt care plans and improve patients’ quality of life.

Ultimately, the combination of reliable outcome measures with innovative treatments like PAAG is leading to more personalised, effective care for those living with Knee OA.

Conclusion

In summary, the Oxford Knee Score and Lysholm scale each offer valuable—and complementary—insights into knee function after PAAG treatment. The OKS tracks improvements in pain relief and everyday mobility, while the Lysholm scale reveals advances in knee stability and performance in higher-impact activities. Together, they provide a well-rounded assessment of recovery, empowering both patients and clinicians to work toward the best possible outcomes. Continued use of these tools, alongside ongoing research, will further enhance the way we treat and manage this common, life-altering condition.

References

Gao, H. C. K., Akhtar, M., Creedon, C., Nar, Ö. O., Verma, T., & Lee, P. Y. F. (2025). Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24 month cohort study. Journal of Clinical Orthopaedics and Trauma, Article 103136. https://doi.org/10.1016/j.jcot.2025.103136

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