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Arthrosamid®’s story started two decades ago. The brainchild of the team at Contura, the product had been in human use for various indications since 2000, and a favourable safety profile had already been established.

Navigating Your Knee Gel Injection Appointment: What to Expect for First-Time Patients

Introduction

If you’re considering a knee gel injection for the first time, it’s perfectly normal to feel a little anxious or unsure about what lies ahead. Knee gel injections, often referred to as viscosupplementation, are a popular, non-surgical treatment that helps manage knee pain caused by osteoarthritis. In this article, we’ll take you through every step of your appointment—from getting ready to recovery—so you can face the process with confidence and ease.

Understanding Knee Gel Injections: What They Are and Who They Help

Knee gel injections involve injecting a gel-like substance into the knee joint to supplement the natural joint fluid. This gel helps to lubricate the joint and cushion the bones, reducing pain and improving mobility. Typically, this treatment is suited for people with knee osteoarthritis who haven’t found enough relief through painkillers or other conservative therapies, like physiotherapy.

Recent studies have shown promising results for a newer type of gel, made of polyacrylamide hydrogel—marketed as Arthrosamid. This injection appears to be a useful alternative to the more traditional hyaluronic acid injections. One study highlights that “iPAAG offers comparable short-term efficacy and modest advantage at 6 months,” meaning it can provide effective relief, especially in the months following treatment. However, its long-term benefits seem to be broadly on par with other treatments.

Preparing for Your Appointment

Getting ready for your appointment is straightforward but important. On the day, wear comfortable, loose clothing that allows your knee easy access. Bring any information about your current medications, as your clinician might ask you to avoid certain drugs, such as anti-inflammatory tablets, before the injection.

You’ll also be asked to fill in consent forms and provide some details about your medical history. Typically, your appointment won’t take long; first, your clinician will examine your knee to make sure this treatment is the right fit for you.

What Happens During the Injection

When it’s time for the procedure, your knee will be cleaned thoroughly to prevent infection. A local anaesthetic may be applied to numb the area, which helps ease any discomfort during the injection. The gel is then carefully injected into your knee joint.

Most patients feel only mild pressure or a brief sting during this process, which usually takes just a few minutes. Your healthcare provider will be with you throughout to ensure you’re comfortable and to answer any questions you might have.

Aftercare: What to Do Once the Injection Is Done

After the injection, you’ll likely stay in the clinic for a short while so the staff can monitor you for any immediate reactions. Most people can stand and walk soon after, but it’s a good idea to arrange for someone to drive you home, just in case.

You might be advised to give your knee a little rest and avoid strenuous activities for a day or two. Using ice packs can help reduce any swelling, and you can take over-the-counter painkillers if needed—your clinician will guide you on aftercare tailored to your situation.

Recovery: How Long It Takes and When to Seek Help

You may start noticing relief from your symptoms within days or weeks. It’s common to experience some mild side effects, like swelling or stiffness around the injection site, but these usually settle quickly.

Research also shows that while pain relief from other treatments like hyaluronic acid or corticosteroids tends to return to normal within a year, “by 12 months, VAS returned to baseline in HA and Steroid, while iPAAG remained slightly improved.” This suggests that some patients experience longer-lasting benefits with polyacrylamide hydrogel.

However, if you ever experience severe pain, fever, prolonged swelling, or anything else concerning, you should contact your healthcare professional promptly. They can help you navigate any complications or suggest other treatment avenues if needed.

Frequently Asked Questions

When can I drive after the injection?
It’s best to avoid driving on the day of your injection. Most patients are able to drive safely the following day.

Is the injection painful?
Thanks to local anaesthetic, discomfort is usually minimal and brief.

When can I get back to exercising?
Light activities can typically be resumed after a few days, but try to avoid heavy or high-impact exercise until your knee feels stronger.

How many injections will I need?
This varies per individual. Your clinician will help determine the right number based on how you respond to treatment.

If you have any other questions or concerns, don’t hesitate to speak openly with your healthcare provider—they’re there to support you.

We hope this guide makes your knee gel injection appointment feel less daunting. Understanding what to expect — the procedure, the aftercare, and the possible benefits — helps you take a positive step towards managing your knee pain more effectively.

References

Aykaç, B., Dinç, M., Nar, Ö. O., Karasu, R., & Bayrak, H. Ç. (2025). Comparative efficacy of polyacrylamide hydrogel versus hyaluronic acid and corticosteroids in knee osteoarthritis: A retrospective cohort study. Medicine, 104(38), e44655. https://doi.org/10.1097/md.0000000000044655

Frequently Asked Questions

AMSK Clinic offers advanced knee gel injections like Arthrosamid® for osteoarthritis, providing a non-surgical option that helps lubricate joints and ease pain. Our clinic’s expert-led care and experience ensure a comfortable, high-quality treatment tailored to each patient’s unique needs.

Arthrosamid® contains polyacrylamide hydrogel, providing effective short-term relief and modestly improved benefit at six months compared to traditional hyaluronic acid injections. AMSK Clinic’s use of the latest treatments ensures patients receive some of the most up-to-date, high-quality care available.

At AMSK Clinic, patients experience a seamless process: a knee examination, local anaesthetic for comfort, and skilled injection by expert clinicians. The procedure is calm and supportive, with staff on hand to answer questions and prioritise your comfort and safety.

After treatment, AMSK Clinic offers comprehensive aftercare, monitoring your recovery and providing tailored advice for rest and rehabilitation. Our experienced team ensures any concerns are addressed promptly, supporting you for the smoothest possible recovery from your knee injection.

AMSK Clinic stands apart due to its reputation, experienced clinicians, and access to the latest treatments like Arthrosamid®. We focus on patient-centred care, cutting-edge methods, and ongoing support, making us a trusted clinic for knee osteoarthritis management.

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